Two new preprints!

We are excited to share our new preprint in which we use the SPOTLITES platform to discover novel effectors for #targetedproteindegradation and other proximity-based approaches!

https://www.biorxiv.org/content/10.1101/2023.07.13.548759v1

After tagging 500+ members of the proteostasis network, we performed systematic recruitment of each tagged protein to a model target using a generic heterobifunctional ligand. Screening against both an endogenous and exogenous protein targets, we identified many interesting hits, including multiple members of the CTLH E3 ligase complex which we validate can be used for TPD!

This work was done in close collaboration with the Ophir Shalem Lab and builds upon their awesome endogenous tagging platform from Yevgeniy Serebrenik and Steph Sansbury– SPOTLITES (Scalable POoled Targeting with a LIgandable Tag at Endogenous Sites)
https://www.biorxiv.org/content/10.1101/2023.07.13.548611v1