NIH Directors Transformative Research Award
Along with our Penn Therapeutic Mechanism colleagues, the lab has been awarded a NIH Director’s Transformative Research Award!
The PTM team is made up of George, Donita Brady, Terrence Gade, Luca Busino and Eric Witze and brings together expertise in translational medicine, mechanistic cell biology, and chemical biology with the goal of developing methods to quantitatively evaluate molecular features of cellular dynamics to improve diagnostics and motivate targeted therapy discovery.
Our Transformative Research Award (TR01) entitled “Unlocking the Chemical Space of Cancer-Associated Perturbations”, will create the Probe Enabled Activity Reporting (PEAR) platform technology.
PEAR leverages chemical biology, chemoproteomics, and chemical imaging approaches to profile alterations in the cancer proteome in response to therapeutic insults in patient samples as a means to predict therapeutic responses and discover unexplored liabilities.